Sepsis and Microbiota: Metabolites of the Microbiota in Sepsis


Prof. Natalia Beloborodova from Negovsky Research Institute, Russiawill join us in ISANH Middle East World Congress 2019 to present presentation entitled "Sepsis and Microbiota: Metabolites of the microbiota in sepsis" during the congress which will be held on March 4-6, 2019 in Muscat, Oman.

"Today sepsis is seen as a life-threatening organ dysfunction caused by the dysregulation of the host response to Infection, but microbiota and their function of maintaining host metabolic homeostasis remain out of sight. In septic patients, the microbial "metabolic conveyor" of the intestine is disturbed, which leads to an excess of metabolic intermediates . The most pathogenetically significant disorders in sepsis may be associated with a violation of biodegradation of metabolites of aromatic amino acids. Some intermediate metabolites accumulated in the blood, which correlated with the progression of multiple organ failure, septic shock and death. We believe that microbiota dysfunction as an invisible organ and disruption of biodegradation of aromatic amino acid products of metabolism is a key mechanism in the development and outcome of sepsis. It is time to look for a targeted strategy to regulate microbiota signaling molecules for survival in sepsis".

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