Gut Microbiota prevents Autoimmune Diabetes via Antimicrobial Peptides

Julien Diana isanh me 2019 updDr. Julien Diana from Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France  will present during the ISANH Middle East World Congress 2019 his study entitled "Gut microbiota prevents autoimmune diabetes via antimicrobial peptides".

The gut microbiota is essential for the normal function of the gut immune system and microbiota alterations are associated with autoimmune disorders. However how the gut microbiota prevents autoimmunity in distant organs remains poorly defined. Using various methods to manipulate the gut microbiota, we demonstrate its critical role in the maintenance of the immune tolerance in the pancreas via the induction of immunoregulatory antimicrobial peptides, hence preventing the development of autoimmune diabetes in mouse model. The expanding knowledge in this field supports the use of gut microbiota manipulation as a novel treatment strategy against type 1 diabetes.


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