Thymoquinone from black seed: an antioxidant or prooxidant?

Hala MuhtasibAccording to Dr Hala Gali-Muhtasib from the American University of Beirut, Lebanon, thymoquinone (TQ) is the most abundant active ingredient of black seed (Nigella sativa L.) and a promising anticancer agent.

TQ targets 9 out of the 10 cancer hallmarks, and protects several organs like kidneys, liver, and heart from standard chemomonotherapy-induced damage.

Ample evidence proves that TQ induces ROS generation and decreases GSH levels in cancer tissues, yet acts as a strong antioxidant and inhibits the production of superoxide radicals and lipid peroxidation, or increases the activities of the antioxidant enzymes superoxide dismutase (SOD),catalase, glutathione (GSH), glutathinone transferase and quinone reductases in normal tissues. Thus, TQ has a dual role and may act selectively as an antioxidant or a pro-oxidant depending on the cellular microenvironment. 

You can meet Dr 
Hala Gali-Muhtasib during Beirut Antioxidant World Congress .

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