Systemic Markers of Oxidative Stress in Hyperlipidemia: What is the clinical relevance?

J Saleh

Prof. Jumana Saleh, Associate Professor of Biochemistry at College of Medicine of Sultan Qaboos University, Oman and Vice-President of ISANH Middle East gave a presentation during the 2nd ISANH Middle East Congress: Beirut Antioxidants World Congress about the Systemic Markers of Oxidative Stress in Hyperlipidemia.

What is the clinical relevance?

A vast number of studies have shown significant associations between oxidative markers and disease. However, very few of these markers are utilized as clinical tools that serve as diagnostic markers or therapeutic targets. Low abundance of circulating oxidative markers and their unstable modifications renders them less cost- effective as clinical tools compared to other biochemical markers.

However, oxidative modifications forming protein carbonyls and lipid oxidation products are more stable and may therefore overcome this shortcoming especially with the development of sensitive kits. Measuring these markers may be useful in detecting and managing disorders associated with hyperlipidemia. Metabolic disorders including Insulin resistance, cardiovascular disease, non-alcoholic fatty liver and congenital hyperlipidemias are becoming of major concern in the Middle East.

Here we explore the use of oxidative markers in hyperlipidemic disorders and their potential clinical use in this area of the world. 

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