Role of different channels in the chemotherapeutic drug-induced mitochondrial oxidative stress, apoptosis and calcium signaling in peripheral pain
During Beirut Antioxidants World Congress, Pr Mustafa Naziroglu from the will summarize the recent experimental research findings on how the chemotherapeutic drug-induced oxidative stresses, TRPM2 and TRPV1 activations are regulated in peripheral pain by antioxidants such as selenium and melatonin.
According to Pr Naziroglu: "Peripheral neuropathies are a common side effect of treatment of various chemotherapeutics. Peripheral sensory neuropathy is a significant dose-limiting side effect of these drugs. Symptoms of paclitaxel-induced neuropathy is usually sensory and peripheral, presents itself as a mechanical allodynia / hyperalgesia, tingling and numbness. The calcium ion (Ca2+) permeable transient receptor potential (TRP) melastatin 2 (TRPM2) and vanilloid 1 (TRPV1) are two subfamilies of the TRP family, members of the melastatin and vanilloid subfamilies, respectively. [...] Recently the team of Pr Naziroglu observed modulator role of selenium and melatonin on apoptosis, oxidative stress and calcium entry through TRPM2 and TRPV1 channels in DRG neuron of diabetic rats (3). Hence, similar protective effects of selenium and melatonin may occur in the anti-cancer drugs-induced neuropathic pain of rats and the subject should be investigated in a rat model."
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About Pr Mustafa Naziroglu:
Professor Mustafa Nazıroğlu received his PhD (Physiology) in Fırat University at 1996. Currently, he is working as Head of Departments of Biophysics and Neuroscience in Suleyman Demirel University, Medical Faculty. He has successfully completed his administrative responsibilities as Head of department, Head of Congress organization committee, director of Neuroscience Research Center in SDU. As chair of congress, he organized 1st, 2nd, 3rd, 4th, 5th and 6th biennale International Congress in World Congress of Oxidative Stress, Calcium Signaling and TRP Channels between 2006 and 2016, Isparta, Turkey. (www.cmos.org.tr). Professor Nazıroğlu is serving as an editorial member of several reputed journals like ‘Biological Trace Element Research’, ‘Journal of Cellular Neuroscience and Oxidative Stress’, ‘Scientific Report (Nature publishing)’, ‘Frontiers in Physiology’ and ‘Current Neuropharmacology (Guest Editor)’. He is also review editor in Frontiers in Membrane Physiology and Biophysics. He authored 186 international research and 14 review articles and 4015 citations in SCI-Thompson and 6 international book chapters (H factor 33). He has honored as NATO Research Fellowship, Martin-Luther University, Halle-Saale, Germany, (1999-2000), ‘Young Investigative Scientist Award (2001), UC-Berkeley, USA, Alexander von Humboldt (AvH) Research fellowship owner (2002-2005), Medical Faculty, RWTH-Aachen, Germany, Encouragement Award of Scientific and Tech. Res. Council (TUBITAK), Ankara, Turkey (2006), Howard Hudges Medical Institute (USA) support (2009), Khwarizmi International Award (2012), Scientific Research Award of Turkish Neurosurgery Society (2016).