Modulators of oxidative stress in alcoholic liver injury and regeneration

LakshmanPr Raj Lakshman from the Lipid Research laboratory, VA Med Center & The Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, DC will give a presentation about Oxidative stress & liver: Modulators of oxidative stress in alcoholic liver injury and regeneration during ISANH Middle East World Congress 2016.

According Pr Lakshmann, the pro-fibrogenic gene, Wnt/β-catenin signaling pathway is well established to play a major role in hepatic fibrogenesis. PI proposes that hepatic fibrogenic process is negligible in normal liver because nucleoredoxin (NXN), a key liver antioxidant, interacts with Dvl that prevents frizzled (Fzd) to form Fzd: Dvl complex leading to preferential phosphorylation and consequent degradation of β-catenin via the proteasomal pathway. However, chronic alcohol-induced reactive oxygen species oxidize NXN and dissociate Dvl from NXN: Dvl complex resulting in inhibiting GSK3β and consequent stabilization and translocation of β-catenin into the nucleus, where it activates hepatic fibrogenesis. Resveratrol is a natural polyphenol found in grapes that has strong phytoestrogenic and antioxidant properties.

Pr. Lakshman proposes to discuss how alcohol abuse affects these complex signaling interactions in hepatic fibrogenesis, and the protective role of resveratrol in blocking these fibrogenic actions of chronic alcohol exposure.

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